Replication of these results by other research groups in a wider range of populations is required, however, before definite conclusions can be made
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In rodent models of acute ischemic stroke induced by middle cerebral artery occlusion (MCAO), semaglutide treatment resulted in a substantial reduction in the volume of the resultant brain infarct by 48%63% and facilitated improved functional recovery ( 4.4 Metabolic dysfunction and other models Semaglutides capacity to ameliorate cognitive deficits induced by a high-fat diet in murine models underscores its potential to directly mitigate the neurological consequences associated with metabolic disorders ( 4.5 Translational limitations and contradictory evidence Despite substantial neuroprotective evidence observed in numerous animal models, it is imperative to recognize significant translational limitations and some contradictory findings
In melanoma TAMs, CD163 and HMOX1 expression is elevated, in line with the heme scavenger phenotype observed in vitro in M2 macrophages [62] (Figs
