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Timing of administration : Taking tirzepatide at a consistent time each week, preferably when patients can rest if needed, may improve tolerability

In OA models, ACSL4 inhibition dramatically decreases ferroptosis-associated lipid peroxidation ( in vitro models, inhibiting cartilage chondroptosis and improving OA ( Excessive lipid metabolic reprogramming in OA significantly raises ferroptosis risk, so targeting lipid synthesis, transport, and degradation represents a promising upstream approach to reducing ferroptotic damage

doi: 10.3389/fendo.2022.886451 21 ArikanTA

Guasch-Ferr M, Hruby A, Toledo E, Clish CB, Martnez-Gonzlez MA, Salas-Salvad J, et al

Species differences in the distribution of drug-metabolizing enzymes in the pancreas