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We further demonstrated important roles of Sirt1 and transcriptional factor Foxo-1 in mediating the function of exendin-4 in regulating adiponectin expression

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doi:10.1056/NEJMoa2410027 Nicholls SJ, Pavo I, Bhatt DL, et al

Additionally, because the program was delivered as an integrated model as a real-world study without a separate control group for the app, medication, or coaching components, we cannot isolate the incremental effect of the digital coaching component, which would be better evaluated through a more traditional randomized control trial design