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Resistance training is instrumental for building and maintaining lean muscle mass and strength

The Phase 2 Weight-Loss Signal In the published Phase 2 dose-escalation trial (NCT04881760, N=338, 24 weeks), participants receiving retatrutide 12 mg achieved a mean body weight reduction of 17.5% versus 1.6% with placebo (P 271 nmol/L) confirms functional tissue deficiency even when serum B12 appears borderline normal

Activities should be enjoyable and sustainable, whether that involves structured exercise, active travel, or increased general movement throughout the day

Eur J Clin Pharmacol 2010;66:1189-97

Ultimately, the goal should be to establish lifestyle habits that support weight maintenance if or when peptide use is discontinued