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This disruption can lead to the manifestation of autistic symptoms ( 3 Research on the association between GABA and ASD 3.1 The relationship between GABAergic interneurons abnormalities and ASD In the mammalian brain, inhibitory GABAergic neurons are primarily interneurons, which include parvalbumin (PV)-expressing interneurons, somatostatin (SST)-expressing interneurons, vasoactive intestinal peptide (VIP)-expressing interneurons, and interneurons expressing the ionotropic serotonin receptor (5HT3a) ( Figure 1 )

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doi:10.1177/0300060518786918

Applying an ice pack or cold compress may also bring relief