Semaglutide , a GLP-1 receptor agonist, works by mimicking the natural hormone GLP-1, which plays a key role in regulating appetite and satiety
8 The Cleveland Clinic clarifies that while adjusting GLP-1 dosages is a common, safe practice for healthcare providers and patients under their strict supervision, microdosing compounded versions of GLP-1swhich are not FDA-approvedis a different practice with its own potential safety and quality risks
PlexusDx does not sell, prescribe, or recommend any therapeutic peptide outside the GLP-1 category covered by its protocols
doi: 10.2337/db21-0848 Summary Keywords GLP-1 - glucagon-like peptide-1, GIP - glucose-dependent insulinotropic peptide, obesity, incretin, pharmacology Citation Douros JD, Flak JN and Knerr PJ (2025) The agony and the efficacy: central mechanisms of GLP-1 induced adverse events and their mitigation by GIP
Moving Forward If you're considering a GLP-1 medication, here's what you need to know in plain terms: Buying these medications online without a prescription is not safe Taking them without proper screening means you may not know if they're safe for you Managing dosing on your own significantly increases your risk of side effects and poor results Without nutritional guidance, you may lose muscle instead of fat Long-term success requires more than a prescription
