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Hypertension (57.8%), depression (54.3%), hypercholesterolemia (52%), and obesity (44.7%) were the most common risk factors for transgender stroke survivors

[DOI] [PubMed] [Google Scholar] Kalgutkar AS, Vaz AD, Lame ME, Henne KR, Soglia J, Zhao SX, Abramov YA, Lombardo F, Collin C, Hendsch ZS, and Hop CE (2005b) Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4

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If semaglutide helps reduce craving or modifies how the brain responds to reward cues, that could help explain why lower risks were seen in substance use outcomes