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There are several factors that increase the risk of developing OA

Several limitations could be addressed in future studies

Additional areas of research include: Tissue repair and wound healing models Collagen and elastin production pathways Anti inflammatory response Hair growth studies Wrinkle depth and skin density observations Some experimental models reference administration methods such as topical application and injection site observation

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In women with PCOS, treatment with metformin (MET) ameliorated the insulin sensitivity and decreased the androgens levels, but the limitations to MET use are its gastrointestinal side effects