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Improvements in HOMA-IR, fasting glucose, and triglycerides were seen broadly across the cohort following semaglutide 12 , regardless of whether DunedinPACE or PCGrimAge declined over the study period

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(5) the fact that treatment interferes with appetite and the pleasure of eating, perhaps due to interference by the GLP-1 RAs with the reward system of the CNS (121), which may be experienced negatively by some