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A 2023 observational study of 47 patients using both agent classes reported modest synergistic weight loss (additional 35 lbs over 12 weeks compared to single-agent) but also a 34% incidence of nausea, dizziness, or appetite suppression beyond baseline tirzepatide side effects

Examples include proton pump inhibitors (PPIs) and Histamine H2 receptor agonists (H2 blockers), which doctors prescribe to treat indigestion, heartburn, and gastroesophageal reflux disease (GERD)

Analysis of stool samples can reveal the presence of inflammatory markers, such as calprotectin and lactoferrin, which indicate heightened immune activity and intestinal inflammation

Patients with a history of GI sensitivity who want proactive gut support before starting or escalating GLP-1 medication

The goal of NAD+ therapy is often to enhance energy, cognitive function, and cellular repair by replenishing the NAD+ that diminishes with age