It is designed for multi-pathway signaling studies spanning ECM remodeling, NO/VEGF signaling, actin regulation, and NF-B suppression
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Machine learning models integrating these metabolites with gut microbiota profiles (e.g., Gemmiger abundance, SCFA-producer/proteolytic bacteria ratios) demonstrate superior DKD risk stratification compared to traditional markers alone (AUC 0.830.93) (136, 138, 152)