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Notably, proglucagon is cleaved in an alternative fashion by PC2 in pancreatic cells to yield glucagon, but not GLP-1/2

They found these molecules are particularly effective at reaching deep brain regions involved in value assignment

People with obesity or diabetes can have low vitamin B12 (especially if they take metformin, a common diabetes drug)

This helps prevent skin irritation and ensures proper medication absorption

2 To guide these conversations effectively, providers may benefit from grounding treatment recommendations in a continuum-of-care approach, one that reflects obesity as a chronic condition requiring ongoing, evolving support and acknowledges the potential out-of-pocket costs that can influence follow-through over time