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For those who struggle with consistent sleep or have high-stress lifestyles, evening supplementation can act as a "top-off" for the bodys internal reservoir, helping to mitigate the impact of a restless night

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This response is partially mediated by CGRP and/or CSD, and involves oxidative stress, mitochondrial dysfunction, the assembly of NLRP3 inflammasomes, activation of microglia, and the reactivity of astrocytes