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Evidence from human and animal studies indicates that food intake fluctuates during the menstrual cycle, because gonadal steroid hormones (estradiol and progesterone) are key regulators of energy uptake

Biomolecules 13 (7), 1156

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(2012) demonstrated: Statistically significant reductions in visceral adipose tissue of approximately 1518% over 26 weeks compared to placebo Meaningful increases in IGF-1 levels Improvements in triglyceride profiles in some patient subgroups Effects were partially reversed upon discontinuation, suggesting that sustained benefit requires ongoing therapy The consistency of the VAT reduction finding across multiple trials is what anchors tesamorelin's clinical utility

doi: 10.1016/j.cell.2015.12.056 71 DebostJ