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These findings, and recent evidence that a delayed-release formulation of metformin with minimal systemic absorption retains its glucose-lowering efficacy [15], suggest that the glucose-lowering effects of metformin are strongly influenced by effects on the gut

Phase 2 trial results have shown promising efficacy in reducing liver fat content and improving lipid profiles

The four-year trial did not reveal any new safety concerns

The compound maintains chemical stability, yet with thermal and acidic resistance, while being susceptible to alkaline hydrolysis (Wang et al., 2024)

Limitations to keep in mind This was a genome-wide association study, not a randomised controlled trial