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Organ Growth Concerns at High Doses Because IGF-1 acts on all tissue not just muscle megadosing for extended periods may promote organ tissue hypertrophy, including intestinal walls and heart tissue

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Studies have also indicated that elevated TNF- and dysregulated iron homeostasis often reinforce each other in tumor or inflammation models, collectively driving cell damage and death (120)

Semaglutide enhances glucose-dependent insulin secretion from pancreatic beta cells, meaning insulin release occurs primarily when blood glucose levels are elevated