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Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response

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In an ongoing debate, two major sources have been proposed: de novo synthesis of Put-GABA by an aldehyde dehydrogenase 1a1 (Aldh1a1) dependent pathway and/or reuptake of extracellular GABA originating in other cells by the transporter GAT1 (Tritsch et al., 2014