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In fibrosis-related contexts, it has also been described as a regulator of pathways related to tissue remodeling[2]

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Can have additive effects with other supplements that lower blood pressure, such as omega-3 fatty acids

They catalyze the decarboxylation of pyruvate, -ketoglutarate, 2-oxoadipate, and branched-chain amino acids (BCAA) to form acetyl-coenzyme A (CoA), succinyl-CoA, glutaryl-CoA, and derivatives of BCAA, respectively ( Figure 1 )

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