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This review aims to comprehensively explore the immunological, genetic, epigenetic, and environmental factors underlying AA, with a focus on immunemediated mechanisms

These include inhibiting the JAK2STAT3 signaling pathway, reducing GFAP expression, blocking inflammatory pathways such as NF-B, regulating neurotransmitter secretion such as GABA and modulating APOE expression to control astrogliosis 81,137,138

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Primarily, it is used for the treatment of Anemia

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