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Harnessing the co-vulnerabilities of amino acid-restricted cancers

Furthermore, many of the hydrophobic and charged residues involved in heterodimerization and salt-bridge formation (as described for hTAF12hTAF4) (27) were conserved between the two CaTaf12 variants (Figure S5B)

MOTS-C is a mitochondrial-derived peptide that improves cellular insulin sensitivity and metabolic efficiency essentially making the cellular machinery more receptive to fat burning

For activation by glutathione (GSH), a 50 mM GSH stock solution in PBS was added to the mixture containing compound 6a to a final concentration of 5 mM