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It has recently been demonstrated that in many cancer cell lines, including leukemia (L1210FR), ovarian (Ov2008, ID8), colon (Colo-26), mastocytoma (P815), lung (M109), renal (RENCA, RD0995), and breast (4T1, JC, MMT06056) cancer cell lines, biotin receptors are overexpressed more than folate and/or vitamin B-12 receptors (155, 156)

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In drosophila, TSC1/TSC2 complex acts to antagonize insulin signaling and negatively regulate cell growth and size