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Grunberger G, Sherr J, Aleppo G, et al

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Appetite signals can begin, but measurable weight change in the first week was not a documented trial outcome

Why It Pairs So Well With GLP-1 Agonists GLP-1 agonists like Retatrutide create a caloric deficit through multiple routes: appetite suppression, slowed gastric emptying, and (in Reta's case) glucagon receptor agonism that drives additional energy expenditure