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The most common side effects reported in SURMOUNT trials were gastrointestinal, including nausea, vomiting, constipation, and diarrhea, typically occurring during dose escalation and diminishing over time

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Existing GLP1R agonists come with boxed warnings of thyroid cancer and pancreatitis, based mainly on rodent studies, where the effects of GLP1R agonism have noted species differences (For example, weight loss in rodents is mainly due to increased energy expenditure, whereas in humans it occurs via less food intake [54] )

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Doctors also recommend not exceeding 2000mg of Glutathione per day and avoiding long-term use, as it may lead to poisoning and other dangerous complications