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1 Introduction Schizophrenia (SZ) is a chronic brain disorder characterized by genetic heterogeneity and neuropathological alterations, with high mortality rates ( Current evidence from genetics, molecular neuropathology, and clinical studies underscores the importance of immune factors in both the pathogenesis and treatment of schizophrenia ( Figure 1 )

Onofrj M1, Fulgente T, Melchionda D, Marchionni A, Tomasello F, Salpietro FM, Alafaci C, De Sanctis E, Pennisi G, Bella R, et al

Glutathione is the master antioxidant (scavenging free radicals) and master detoxifier

Some patients benefit from biomarker assessment or genetic context to clarify whether slower response reflects normal individual variation or signals need for treatment adjustment

Rather, it helps calibrate cellular responsiveness so that excitation remains productive rather than damaging [2]