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24 Free carnitine can be depleted if it remains bound to unprocessed fatty-acids due to a reduction in mitochondrial fatty-acid beta-oxidation

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The most comprehensive evidence comes from three sources: the Phase 2 trial published in the New England Journal of Medicine , the Phase 3 TRIUMPH-4 trial, and a systematic review and meta-analysis that synthesized data from 878 total participants across three randomized controlled trials

Previous literature has reported that oral LC therapy can improve progressive sperm motility to 20.1 8.8% and sperm motility to 38.3 9.7%, and the pregnancy rate of couples with ASZ was 19.6% [7, 17]