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As this was the first study manipulating TGF 1/SMAD3 signaling in these cells, it is possible that this signaling pathway could be generating other effects on these cells that have not been investigated, such as affecting junctional adhesion molecules or proteins of the adherens junction

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Patients with pre-existing cardiac conditions , particularly those with heart failure or significant arrhythmias, should be monitored appropriately when initiating GLP-1 receptor agonist therapy

A: Sometimes the body may not be able to tolerate the full dose due to side effects

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