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Future trials are needed to confirm whether GLP-1 drugs might be effective in preventing Alzheimers disease. Declared interests: Prof Sir John Hardy: I have consulted for Eisai and Eli Lilly Prof Paresh Malhotra: I receive research funding from NIHR, MRC, Dementia Platforms UK, Alzheimers Research UK, the Football Association, British Heart Foundation and Alzheimers Society

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These changes typically stabilise within three to six months as the body adjusts to the new metabolic state