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"The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health." Oxidative medicine and cellular longevity 2012 (2012) Pickart L

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The protein family is evolutionarily conserved in nearly all eukaryotes, only missing in a few, highly diverged eukaryotes such as Giardia lamblia and Encephalitozoon cuniculi 4

Thus, synthetic lethality is achieved by co-targeting CMPK/TMPK and GSH in CML-BC cells that have high level of GSH

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