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These findings, along with the fact that the lung can normally maintain GSH for long periods even with the oxidant burden of CS, lend credence to the theory that disease symptoms could arise when adaptive responses fail or are dysfunctional

Patients with type 2 diabetes and depressive symptoms received chronic candesartan administration for at least three months, which significantly improved interpersonal sensitivity and depression ratings and reset the HPA axis by reducing the sensitivity of the adrenals to ACTH and expression of AT1R (148)

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Xanthine oxidase inhibitors (XOIs) Xanthine oxidase catalyzes the conversion of purine metabolites to uric acid (UA)