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This gene is located on chromosome 2q37.3 and is responsible for encoding D-2-hydroxyglutarate dehydrogenase, whose primary function is to convert D-2-hydroxyglutarate (D-2-HG) into -ketoglutarate [53]

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GLP-1R activation leads to an increase of intracellular cyclic adenosine monophosphate (cAMP), which activates protein kinase A (PKA) and phosphoinositide 3-kinase (PI3K) with a subsequent activation of some downstream signaling pathways associated with cell survival [42]