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Therefore, restoration of gene pattern characteristic of healthy stem cells, which leads to activation of integrins and p63 cellular pathways may be another target of GHKs gene modulatory activity relevant to skin regeneration. [4] [5] GHK Basic peptide and the Ubiquitin Proteasome System (UPS) The Ubiquitin Proteasome System (UPS) is considered to be a crucial mechanism responsible for regulating and removing damaged proteins within the cell