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Biochemically, tirzepatide is a larger and more complex peptide with sequence elements and receptor-binding domains optimized to engage two incretin receptors, while semaglutide is engineered specifically for high-affinity GLP-1R activation

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Prior studies demonstrated GLP-1s confer anti-inflammatory, cardiometabolic and endothelial-protective benefits, Cheema said

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Likewise, there was a greater response in patients with a family history of migraine.105 Importantly, neither injectable sumatriptan nor the nasal spray are available in Mexico, and so studies are needed to document the efficacy of oral treatment