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L-citrulline may preserve sperm DNA integrity by attenuating direct oxidative DNA damage via reduced mitochondrial ROS and suppressing Trp53-dependent apoptotic pathway activation through maintained mitochondrial membrane potential

May help fight against autoimmune disease

10.1038/s41580-020-0230-3 94 Silva-AdayaD.GonsebattM

Laboratory studies investigate effects on fibroblast cultures and extracellular matrix synthesis pathways

Scientific Overview A 4-amino acid synthetic tetrapeptide modeled on pineal gland epithalamin that activates telomerase and modulates circadian gene expression in preclinical and early human studies