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Semaglutide and NYHA Functional Class in Obesity-Related Heart Failure With Preserved Ejection Fraction: The STEP-HFpEF Program

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While the vasodilatory effects of testosterone have been suggested in some studies, the mechanisms and the overall impact on cardiovascular health arent entirely clear

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The risk was driven by the synthetic progestin What Modern Research Shows The French E3N cohort study (80,000+ women) found no increased breast cancer risk with bioidentical estradiol plus micronized progesterone for up to 5 years The "timing hypothesis" shows women starting HRT within 10 years of menopause receive cardiovascular benefit rather than harm The Danish Osteoporosis Prevention Study showed reduced heart failure, MI, and mortality over 16 years of follow-up Major medical organizations NAMS, Endocrine Society, and IMS now endorse HRT for symptomatic women within the appropriate window Risks and Contraindications Hormone therapy is not risk-free, and we believe in complete transparency