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Current research is constrained by methodological limitations, including small sample sizes, inadequate control of confounding variables, and substantial heterogeneity in outcome measures, which collectively compromise the reliability and generalizability of findings

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J Am Coll Cardiol 35(7):17781784 Diguet N, Trammell SAJ, Tannous C, Deloux R, Piquereau J, Mougenot N, Gouge A, Gressette M, Manoury B, Blanc J, Breton M, Decaux JF, Lavery GG, Baczk I, Zoll J, Garnier A, Li Z, Brenner C, Mericskay M (2018) Nicotinamide riboside preserves cardiac function in a mouse model of dilated cardiomyopathy

Discuss any persistent or severe GI side effects with your provider in some cases, a slower titration schedule is the right solution rather than discontinuing therapy entirely

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