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furzeri ), a naturally short-lived vertebrate with a lifespan ranging from 4 to 8 months 13,26,31 , and a plethora of spontaneous age-dependent transformations, including neoplasias 73 , neurodegeneration 74 and intestinal dysbiosis 22

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Adequate hydration is essential for maintaining healthy oral mucosa, and dehydration can predispose individuals to dry mouth (xerostomia) and subsequent ulceration