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Abbreviations: VTA: ventral tegmental area, NAc: nucleus accumbens, NTS: nucleus tractus solitarius, LH: lateral hypothalamus, DMHipp: dorsomedial hippocampus, LDTg: laterodorsal tegmental nucleus, LS: lateral septum, CeA: central amygdala, PVN: paraventricular nucleus, DA: dopamine, : decreased, : increased, MAO-A: monoamine oxidase A, COMT: catechol-O-methyltransferase, D1-MSN: D1-type medium spiny neuron, OX1R: orexin-1 receptor, HPA: hypothalamicpituitaryadrenal axis

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Increased mitochondrial NAD+ may promote the activity of SIRT4, an inducer of adipogenesis, while decreased nuclear NAD+ may decrease the activity of SIRT1, a negative regulator of adipogenesis ( via multiple independent mechanisms

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