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Vegans and vegetarians are especially likely to be low on B12 because B12 is only naturally present in animal products and meat

The lack of evidence-based best-practice methodology hampers reproducibility (preclinical or clinical), and translation (between preclinical and clinical work)

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in 2022, Martins & colleagues showed that women with overweight who experienced an average weight loss of 16% had a metabolic adaptation of approximately ~50kcal/day. Meaning, while metabolic adaptation does occur, its not likely the primary culprit of a stalled diet