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Outside of a clinical trial, access to an unlicensed investigational medicine such as retatrutide would only be possible under specific MHRA frameworks for example, the Early Access to Medicines Scheme (EAMS) , which requires a positive scientific opinion from the MHRA before use outside trials can be considered

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Subjects with known clinically relevant comorbidity, acute illness, serious infectious disease for 4 weeks prior the product intake, abnormal screening laboratory tests, and abnormal blood pressure (systolic blood pressure 139 mmHg and/or diastolic blood pressure 89 mmHg) were excluded, although subjects with normal blood pressure taking anti-hypertensive medication were included

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Some clinicians recommend a washout period (stopping one before starting the other)