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Exenatide also did not appear to induce appetite suppression, a major effect of GLP-1RAs, as the food intake of the mice remained steady
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Both medications slow gastric emptying, but tirzepatide typically causes more pronounced GI effects
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The most frequently reported issues include: Nausea and occasional vomiting Diarrhea or constipation Abdominal pain and decreased appetite Rare But Serious Risks Like all GLP-1s, Rybelsus carries a black-box warning for a rare risk of thyroid C-cell tumors, based on rodent studies
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