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What microdosing means for oral GLP-1 Microdosing typically involves taking a dose below the standard starting level, often daily, to achieve subtle appetite modulation without the gastrointestinal side effects that come with standard dosing

Genuinely effective obesity drugs, as GLP-1s appear to be, should have a positive impact on the bottom line of US health insurers like Cigna (CI), United Healthcare (UNH), Humana (HUM) and Centene (CNC) in the long term while harming companies paying for these very expensive and likely to be in-demand medications like Insperity (NSP) and Robert Half (RHI)

Studies on semaglutide (a similar GLP-1 agonist) in patients with depression show mixed but generally neutral to positive mood outcomes, though individual responses vary widely

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Molecules and Cells, 42 (12), 821827