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[1] In humans, ergothioneine is acquired exclusively through the diet and accumulates in erythrocytes, bone marrow, liver, kidney, seminal fluid, and eyes

Pheomelanin primarily comprises sulfur-containing benzothiazine and benzothiazole derivatives

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doi: 10.1111/j.1471-4159.2011.07189.x 125 TangGGutierrez RiosPKuoSHAkmanHORosoklijaGTanjiKet al

In a phase 3 trial (REDEFINE-2) of adults with T2DM and a BMI of 27 kg/m 2 and above, combining the GLP-1 receptor agonist semaglutide with the long-acting amylin analogue cagrilintide resulted in greater weight loss than placebo at 68 weeks (13.7% vs 3.4%)