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Experimental observations suggest FOXO4-DRI could be relevant for exploring how proteasomal function might be preserved in cardiac tissues, with implications for studying age-associated heart conditions

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PMID: 37062667, PMCID: PMC10198892, DOI: 10.1016/j.amjcard.2023.03.009

32 this issue), we have extended these findings to human volunteers without obesity and further showed that the profound muscle increases induced by blocking both GDF8 and ActA in humans are also accompanied by a loss of fat