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Key Takeaways for Providers Immediate Opportunities (Next 30 Days) Review patients for higher-dose semaglutide candidates Assess plateau patients for muscle-preserving therapies Update patient education about oral GLP-1 options Begin body composition monitoring Strategic Planning (Next 90 Days) Prepare workflows for oral GLP-1 management Develop cardiovascular risk reduction protocols Consider integrating technology/AI tools Stay informed on ultra-long-acting formulation results Conclusion Septembers developments reflect the continued maturation of GLP-1 therapy in 2025

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The treated cells were then washed twice with warm PBS and stained with 10 M DCFH-DA for 30 min at 37 C, following the manufacturers instructions

In the patch-clamp recording, only Ghsr + Glp1r + neuron cells were used for the final analysis

Ethics statement The animal protocol was specifically approved by the Scientific Ethics Committee of Ethics Committee of the School of Public Health, Jilin University (approval No