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AARS1 binds directly to lactate, catalyzes the adenosine triphosphate (ATP)-dependent synthesis of lactate-AMP and mediates widespread lysine lactylation, including that of p53

Moreover, obesity impairs the female reproductive system through interference with the hypothalamic-pituitary-ovarian axis and by affecting ovarian function

BAL was performed by cannulating the trachea and two 750 L aliquots of isotonic potassium phosphate buffer (50 mM) at a pH of 7.4 were instilled and collected by gentle aspiration