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Gastrointestinal symptoms - Diarrhea, constipation, abdominal discomfort, vomiting Reduced appetite - While this contributes to weight loss, some people find it makes eating adequate nutrition challenging Fatigue - Some individuals report feeling more tired, particularly in the first few weeks Injection site reactions - Redness, itching, or mild discomfort at injection sites (for injectable formulations) Most side effects are dose-dependent and tend to improve as the body adjusts

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Most people absorb enough natural B12 that they dont have to worry about additional supplements, but for those with poor nutrition, stomach problems or cancer, B12 can be hard for the body to process

Pharmaceutical GLP-1 drugs often exceed $1,000 per month without insurance coverage