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Demand for GLP-1s, including Novo Nordisk's weight loss treatment Wegovy and diabetes injection Ozempic, has outstripped supply over the last year in the U.S

Ahmann, A

Importantly, discontinuation of semaglutide after 20 weeks of treatment led to regain of body weight, whereas maintaining treatment led to continued body-weight loss over an additional 48 weeks of treatment, underlining that life-long treatment is necessary to maintain treatment effect [37]

Kow CS et al

This facilitates oxidative phosphorylation, ultimately promoting GLP-1 secretion in enteroendocrine cells, thereby delineating a key mechanism for LEOs antidiabetic efficacy