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Altintas also noted that if these findings are confirmed by prospective studies, several important clinical implications emerge. First, clinicians may be less concerned that semaglutide-induced weight loss inherently increases fracture risk in patients with type 2 diabetes

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Meanwhile, the expression of NLRP3, Caspase-1, and IL-18 were obviously enhanced in TAC group, compared to the Sham group, but their expression in TAC + semaglutide group were remarkably lessened, compared to the TAC group, by Western-blot and IHC respectively