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Severe or persistent vomiting, severe abdominal pain, fainting, dehydration, confusion, or symptoms of low blood sugar need prompt medical assessment, especially after a possible dosing error

For adults with a BMI of 40 kg/m2 or higher or those with a BMI of 35 kg/m2 or higher with obstructive sleep apnea or prediabetes, Apovian recommends strongly considering bariatric surgery as a first-line therapy due to very low complication rates and robust and durable weight loss

In this case, quitting can have a great benefit in lowering blood cholesterol levels

The primary difference lies in their scope and oversight

These findings align closely with prior cardiovascular outcome trials and solidify the evidence base by demonstrating consistent benefits in broader patient populations treated in clinical practice