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This is a fundamental tissue biology difference, not a dosing issue

B12 is water-soluble, meaning excess amounts are safely excreted through urine rather than accumulating in your body, making toxicity extremely rare even at high supplement doses

Beyond photographs and shed hair counts, consider tracking subjective factors like scalp health, hair texture, and styling behavior

For example, a study of MTHFR polymorphism genotypes in colorectal cancer patients reported that the frequency of methylated Bcl-2 promoter was significantly higher in individuals with CC genotype than that of those with CT and TT genotypes, and a significant difference of C and T alleles distribution were observed between patients with methylated and unmethylated Bcl-2 promoter 35

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